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CS-W001157 4
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4-Chloropyridine-3-sulfonamide

  • CAS No. 33263-43-3

  • Cat. No. CS-0020161
  • Purity≥98%
  • MDL No.MFCD04038136

*For research and further manufacturing use only, not for direct human use.

4-Chloropyridine-3-sulfonamide|CS-0020161

Structure of 33263-43-3

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General Information

  • CAS No. 33263-43-3
  • Cat. No. CS-0020161
  • Purity ≥98%
  • MDL No. MFCD04038136
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂O₂S
  • Molecular Weight 192.62
  • Synonym(s) 4-Chloropyridine-3-Sulfamide
  • SMILES O=S(C1=C(Cl)C=CN=C1)(N)=O

Description

4-Chloropyridine-3-sulfonamide features a pyridine ring bearing both chloro and sulfonamide substituents at meta positions, enabling strong hydrogen bonding and enhanced solubility. This combination imparts stability and facilitates integration into bioactive scaffolds for medicinal chemistry applications.

Application

4-Chloropyridine-3-sulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its chlorine atom at the 4-position provides a reliable handle for C–X bond formation, while the sulfonamide group offers hydrogen-bonding capability and metabolic stability. The compound exhibits good bench stability and compatibility with diverse reaction conditions, facilitating efficient synthesis of bioactive molecules and functional intermediates in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   73.05
  • LogP   0.3824
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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