Methyl 3,5-dichloro-4-hydroxybenzoate

Name: Methyl 3,5-dichloro-4-hydroxybenzoate
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CAS No. 3337-59-5
Cat. No. CS-0150846
Purity≥98%
MDL No.MFCD00016419

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Methyl 3,5-dichloro-4-hydroxybenzoate|CS-0150846

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Description

Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

Application

Methyl 3,5-dichloro-4-hydroxybenzoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted aromatic systems. The ortho-hydroxyl and ester functionalities provide sites for selective derivatization, while the electron-withdrawing dichloro substituents enhance electrophilicity for subsequent coupling reactions. Its bench-stable nature and compatibility with common protecting group strategies facilitate straightforward purification and integration into multi-step syntheses, particularly in the construction of bioactive heterocycles and pharmaceutical intermediates.

General Information

CAS No. 3337-59-5
Cat. No. CS-0150846
Purity ≥98%
MDL No. MFCD00016419
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆Cl₂O₃
Molecular Weight 221.04
Synonym(s) METHYL-4-HYDROXY-3 5-DICHLOROBENZOATE
SMILES COC(=O)C1=CC(=C(C(=C1)Cl)O)Cl

Computational Chemistry Data

TPSA 46.53
LogP 2.4856
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Methyl 3,5-dichloro-4-hydroxybenzoate

CAS No. 3337-59-5

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