(1-Trityl-1H-imidazol-4-yl)methanol

Name: (1-Trityl-1H-imidazol-4-yl)methanol
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CAS No. 33769-07-2
Cat. No. CS-0045285
Purity≥95%
MDL No.MFCD02179553

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(1-Trityl-1H-imidazol-4-yl)methanol|CS-0045285

Structure of 33769-07-2

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Description

This trityl-protected imidazole derivative serves as a robust scaffold for nucleoside and oligonucleotide synthesis. The bulky trityl group confers exceptional stability during purification and handling, while the methanol-functionalized imidazolyl moiety enables efficient coupling reactions under standard conditions. Designed for high-yield incorporation in sensitive synthetic sequences, this compound delivers reliable protection and orthogonal reactivity.

Application

(1-Trityl-1H-imidazol-4-yl)methanol serves as a robust protecting group strategy for imidazole nucleophiles, enabling selective functionalization in complex molecule synthesis. The trityl moiety provides excellent stability under diverse reaction conditions, facilitates easy purification by precipitation, and can be removed cleanly under mild acidic conditions. This compound functions as a key building block in the construction of heterocyclic scaffolds and peptide conjugates, offering high functional group tolerance and compatibility with standard synthetic workflows.

General Information

CAS No. 33769-07-2
Cat. No. CS-0045285
Purity ≥95%
MDL No. MFCD02179553
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₀N₂O
Molecular Weight 340.42
Synonym(s) 1-Trityl-1H-imidazole-4-methanol
SMILES OCC1=CN(C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=N1

Computational Chemistry Data

TPSA 38.05
LogP 4.2156
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(1-Trityl-1H-imidazol-4-yl)methanol

CAS No. 33769-07-2

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