H-D-Phe(4-Cl)OMe.HCl

Name: H-D-Phe(4-Cl)OMe.HCl
Brand: ChemScene
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CAS No. 33965-47-8
Cat. No. CS-W012647
Purity≥98%
MDL No.MFCD00236920

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

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Description

H-D-Phe(4-Cl)OMe.HCl features a para-chlorinated phenylalanine residue with a stable N-terminal D-amino acid and methyl ester group, offering enhanced metabolic resistance and improved membrane permeability for peptide-based research applications.

Application

H-D-Phe(4-Cl)OMe·HCl serves as a stable, bench-ready building block for peptide synthesis, featuring a D-phenylalanine residue with a para-chloro substituent on the aromatic ring and a methyl ester at the C-terminus. Its hydrochloride salt form enhances solubility and handling, enabling efficient coupling in standard solid-phase protocols. The electron-withdrawing chlorine group modulates electronic properties and metabolic stability, making it valuable for constructing bioactive peptides and peptidomimetics with improved pharmacokinetic profiles.

General Information

CAS No. 33965-47-8
Cat. No. CS-W012647
Purity ≥98%
MDL No. MFCD00236920
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃Cl₂NO₂
Molecular Weight 250.12
Synonym(s) None
SMILES N[C@H](CC1=CC=C(Cl)C=C1)C(OC)=O.[H]Cl

Computational Chemistry Data

TPSA 52.32
LogP 1.8046
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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H-D-Phe(4-Cl)OMe.HCl

CAS No. 33965-47-8

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