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CS-W001157 4
Total: USD 88.00

Cyclopentanecarboxylic acid

  • CAS No. 3400-45-1

  • Cat. No. CS-W007448
  • Purity≥98%
  • MDL No.MFCD00001371

*For research and further manufacturing use only, not for direct human use.

Cyclopentanecarboxylic acid|CS-W007448

Structure of 3400-45-1

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General Information

  • CAS No. 3400-45-1
  • Cat. No. CS-W007448
  • Purity ≥98%
  • MDL No. MFCD00001371
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) Cyclopentylcarboxylic acid; Cyclopentanecarboxylic acid
  • SMILES O=C(C1CCCC1)O

Description

Cyclopentanecarboxylic acid features a rigid, five-membered ring that imparts conformational stability and enhances lipophilicity. This structural rigidity supports its use in medicinal chemistry scaffolds and as a building block for bioactive molecules. The carboxylic acid group enables direct derivatization or salt formation, facilitating purification and handling under standard conditions.

Application

Cyclopentanecarboxylic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of bioactive heterocycles and natural product analogs. Its rigid cyclopentane scaffold imparts conformational restraint, enhancing target specificity in medicinal chemistry applications. The carboxylic acid group facilitates direct derivatization—via esterification, amidation, or activation—for downstream coupling reactions. Bench-stable and readily purified by recrystallization, it functions reliably in standard workflows requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED Patent: WO2006/2956 A1, 2006 ; Location in patent: Page/Page column 33 ; WO 2006/002956 A1
  • Route2
    • null|null
      287-92-3
    • null|null
      201230-82-2
    • ~41%
    • In-stock
      Cyclopentanecarboxylic acid|CS-W007448
      3400-45-1

    References

    • Kirillov, Alexander M.; Karabach, Yauhen Y.; Kirillova, Marina V.; Haukka, Matti; Pombeiro, Armando J. L. Dalton Transactions, 2011 , vol. 40, # 24 p. 6378 - 6381
  • Route3
    • null|null
      872-53-7
    • ~87%
    • In-stock
      Cyclopentanecarboxylic acid|CS-W007448
      3400-45-1

    References

    • Zhao, Junfeng; Mueck-Lichtenfeld, Christian; Studer, Armido Advanced Synthesis and Catalysis, 2013 , vol. 355, # 6 p. 1098 - 1106

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.2612
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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