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Structure of 34113-69-4
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4-Chloro-3-hydroxybenzoic acid features a hydroxyl group ortho to the carboxylic acid and a chlorine substituent at the para position, enabling diverse functionalization. This electron-deficient aromatic scaffold integrates readily into bioactive molecule frameworks, offering enhanced solubility and stability under standard conditions.
4-Chloro-3-hydroxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and carboxylic acid sites. Its ortho-chloro substituent enhances electrophilic substitution reactivity and provides a handle for palladium-catalyzed coupling reactions. The compound exhibits bench stability and facilitates straightforward derivatization, including esterification, amide formation, and Suzuki-Miyaura cross-coupling, making it well-suited for the synthesis of complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335-H400
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Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P405-P501
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Lot numbers can be found on the outside label of a product: