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CS-W001157 4
Total: USD 88.00

4-Bromothiazole

  • CAS No. 34259-99-9

  • Cat. No. CS-W001221
  • Purity≥98%
  • MDL No.MFCD06657592

*For research and further manufacturing use only, not for direct human use.

4-Bromothiazole|CS-W001221

Structure of 34259-99-9

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General Information

  • CAS No. 34259-99-9
  • Cat. No. CS-W001221
  • Purity ≥98%
  • MDL No. MFCD06657592
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂BrNS
  • Molecular Weight 164.03
  • Synonym(s) 4-Bromo-1,3-thiazole
  • SMILES BrC1=CSC=N1

Description

4-Bromothiazole is a bench-stable, moisture-tolerant heterocycle featuring a bromine atom at the 4-position of the thiazole ring. This configuration enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive molecules. The electron-deficient nature of the ring enhances reactivity in palladium-catalyzed transformations. Its compatibility with diverse synthetic protocols makes it a reliable building block for pharmaceutical intermediates and agrochemicals.

Application

4-Bromothiazole serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the thiazole ring via palladium-catalyzed cross-coupling reactions. Its bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, facilitating the construction of complex heterocyclic architectures. The compound exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for medicinal chemistry campaigns and process-scale synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9056
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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