Lot numbers can be found on the outside label of a product:
1-Boc-4-Amino-4-methylpiperidine
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CAS No. 343788-69-2
- Cat. No. CS-W005408
- Purity≥98%
- MDL No.MFCD03265497
*For research and further manufacturing use only, not for direct human use.
Structure of 343788-69-2
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General Information
- CAS No. 343788-69-2
- Cat. No. CS-W005408
- Purity ≥98%
- MDL No. MFCD03265497
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₂₂N₂O₂
- Molecular Weight 214.31
- Synonym(s) Tert-butyl 4-amino-4-methylpiperidine-1-carboxylate
- SMILES CC1(N)CCN(C(OC(C)(C)C)=O)CC1
Description
1-Boc-4-Amino-4-methylpiperidine delivers a protected amine handle for late-stage functionalization in medicinal chemistry. The tert-butyl carbamate group ensures stability and ease of removal under mild acidic conditions. This piperidine derivative features a sterically hindered methyl substituent that modulates basicity and conformational flexibility, enhancing bioavailability in target-directed synthesis workflows.
Application
1-Boc-4-Amino-4-methylpiperidine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted piperidine scaffolds. The Boc group provides excellent stability and orthogonal protection, facilitating straightforward deprotection under mild acidic conditions. Its tertiary amine functionality supports diverse functionalization, including reductive amination and coupling reactions, while the methyl substituent enhances metabolic stability and modulates lipophilicity in bioactive molecule design.
Synthesis
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Route1
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236406-14-7 - ~93%
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In-stock
343788-69-2
References
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PURDUE PHARMA L.P.; SHIONOGI and CO., LTD. Patent: WO2008/89201 A2, 2008 ; Location in patent: Page/Page column 234-235 ; WO 2008/089201 A2
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Route2
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163271-06-5 -
In-stock
24424-99-5 - ~97%
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In-stock
343788-69-2
References
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GLAXO GROUP LIMITED Patent: WO2008/119718 A1, 2008 ; Location in patent: Page/Page column 45 ; WO 2008/119718 A1
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Route3
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872850-48-1 - ~99%
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In-stock
343788-69-2
References
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VERTEX PHARMACEUTICALS INCORPORATED Patent: US2010/137305 A1, 2010 ; Location in patent: Page/Page column 37 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.56
- LogP 1.7347
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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