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CS-W001157 4
Total: USD 88.00

4-Bromo-2-pyrimidinamine

  • CAS No. 343926-69-2

  • Cat. No. CS-W009105
  • Molecule weight174.00
  • Purity≥97%
  • MDL No.MFCD09999168

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-pyrimidinamine|CS-W009105

Structure of 343926-69-2

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General Information

  • CAS No. 343926-69-2
  • Cat. No. CS-W009105
  • Purity ≥97%
  • MDL No. MFCD09999168
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄BrN₃
  • Molecular Weight 174.00
  • Synonym(s) 2-Amino-4-bromopyrimidine; 4-Bromopyrimidin-2-amine; 2-Pyrimidinamine, 4-bromo-
  • SMILES NC1=NC=CC(Br)=N1

Description

4-Bromo-2-pyrimidinamine serves as a key heterocyclic building block for medicinal chemistry and materials science. Featuring a bromine substituent at C4 and an amino group at C2, this pyrimidine scaffold enables efficient cross-coupling reactions and functional diversification. The compound exhibits excellent stability under standard conditions and integrates readily into bioactive molecule design.

Application

4-Bromo-2-pyrimidinamine serves as a versatile building block for the synthesis of pyrimidine-based heterocycles, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Its bromine handle facilitates palladium-catalyzed cross-coupling, while the primary amine group supports derivatization and salt formation. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.8213
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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