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Structure of 344-14-9
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Dimethyl 2-fluoromalonate features a fluorinated malonate core with enhanced electrophilicity at the α-carbon, enabling efficient C–C bond formation in nucleophilic addition reactions. This bench-stable reagent integrates readily into synthetic sequences requiring activated ester equivalents, offering high functional group tolerance and predictable regioselectivity under mild conditions.
Dimethyl 2-fluoromalonate serves as a versatile building block in synthetic organic chemistry, enabling the efficient construction of fluorinated carbocycles and heterocycles via Michael additions, Mannich reactions, and cycloadditions. Its electrophilic fluorine enhances reactivity in nucleophilic substitution processes, while the malonate ester functionality supports facile deprotonation and subsequent functionalization. The compound exhibits good bench stability and is compatible with a range of protecting group strategies, facilitating its use in medicinal chemistry lead optimization and process-scale synthesis.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314-H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: