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(R)-pyrrolidine-2-carboxylic acid

  • CAS No. 344-25-2

  • Cat. No. CS-W020557
  • Purity≥97%
  • MDL No.MFCD00064317

*For research and further manufacturing use only, not for direct human use.

(R)-pyrrolidine-2-carboxylic acid|CS-W020557

Structure of 344-25-2

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General Information

  • CAS No. 344-25-2
  • Cat. No. CS-W020557
  • Purity ≥97%
  • MDL No. MFCD00064317
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₂
  • Molecular Weight None
  • Synonym(s) (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
  • SMILES O=C(O)[C@@H]1NCCC1

Description

(R)-pyrrolidine-2-carboxylic acid is a chiral building block featuring a stereodefined pyrrolidine ring with a carboxylic acid at the C2 position. This configuration imparts distinct stereochemical control in asymmetric synthesis, enabling precise integration into peptidomimetics and bioactive heterocycles. The compound exhibits favorable solubility and stability under standard conditions, facilitating use in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Mazzini, Claudio; Sambri, Letitia; Regeling, Henk; Zwanenburg, Binne; Chittenden, Gordon J. F. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 22 p. 3351 - 3356
  • Route2
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      4128-31-8
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    • In-stock
      (R)-pyrrolidine-2-carboxylic acid|CS-W020557
      344-25-2

    References

    • EP315716 A1, ;
  • Route3

    References

    • European Journal of Organic Chemistry, , # 7 p. 1253 - 1264

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.177
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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