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Structure of 345-24-4
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5-Bromo-2,4-difluoronitrobenzene features a nitro group flanked by two fluorine atoms and a bromine substituent, creating a highly reactive aryl halide scaffold. This electron-deficient system enables efficient coupling in cross-coupling reactions, particularly under palladium catalysis. The molecule's stability under standard conditions supports reliable use in synthetic sequences for pharmaceutical intermediates and functional materials.
5-Bromo-2,4-difluoronitrobenzene serves as a versatile building block in nucleophilic aromatic substitution (SNAr) reactions, enabling efficient access to functionalized arylamines and heterocycles. The ortho-fluoro groups facilitate selective displacement under mild conditions, while the bromo and nitro substituents provide orthogonal reactivity for downstream coupling processes. Bench-stable and readily purified by recrystallization, it functions reliably in the synthesis of pharmaceutical intermediates and advanced materials.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: