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CS-W001157 4
Total: USD 88.00

(4-Fluorophenyl)(phenyl)methanone

  • CAS No. 345-83-5

  • Cat. No. CS-0130360
  • Purity≥97%
  • MDL No.MFCD00000352

*For research and further manufacturing use only, not for direct human use.

(4-Fluorophenyl)(phenyl)methanone|CS-0130360

Structure of 345-83-5

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General Information

  • CAS No. 345-83-5
  • Cat. No. CS-0130360
  • Purity ≥97%
  • MDL No. MFCD00000352
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉FO
  • Molecular Weight 200.21
  • Synonym(s) P-FLUOROBENZOPHENONE
  • SMILES O=C(C1=CC=C(F)C=C1)C2=CC=CC=C2

Description

(4-Fluorophenyl)(phenyl)methanone features a fluorinated aryl group that enhances electronic modulation and metabolic stability. This ketone integrates readily into synthetic scaffolds requiring electron-deficient aromatic character. The structure supports efficient coupling reactions under standard conditions, offering predictable reactivity in pharmaceutical and materials synthesis workflows.

Application

(4-Fluorophenyl)(phenyl)methanone serves as a versatile aryl ketone building block for pharmaceutical and agrochemical synthesis. Its structure enables direct incorporation into diverse heterocyclic scaffolds via standard condensation, cyclization, and transition-metal-catalyzed coupling reactions. The fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the bench-stable ketone group offers predictable reactivity in nucleophilic additions and reductions.

Synthesis

  • Route1
    • In-stock
      4-Fluorobenzeneboronic acid|CS-D1103
      1765-93-1
    • null|null
      98-88-4
    • ~99%
    • In-stock
      (4-Fluorophenyl)(phenyl)methanone|CS-0130360
      345-83-5

    References

    • Zhang, Li; Wu, Junliang; Shi, Lijun; Xia, Chungu; Li, Fuwei Tetrahedron Letters, 2011 , vol. 52, # 30 p. 3897 - 3901
  • Route2

    References

    • Lin, Xiao-Fang; Li, Yao; Li, Shuang-Yan; Xiao, Zheng-Kang; Lu, Jian-Mei Tetrahedron, 2012 , vol. 68, # 29 p. 5806 - 5809
  • Route3
    • null|null
      1227828-27-4
    • ~83%
    • In-stock
      (4-Fluorophenyl)(phenyl)methanone|CS-0130360
      345-83-5

    References

    • Tang, Pingping; Ritter, Tobias Tetrahedron, 2011 , vol. 67, # 24 p. 4449 - 4454

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.0567
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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