Tert-butyl (4-chloro-3-hydroxyphenyl)carbamate

Name: Tert-butyl (4-chloro-3-hydroxyphenyl)carbamate
Brand: ChemScene
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CAS No. 345893-27-8
Cat. No. CS-0273187
Purity≥98%
MDL No.None

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Tert-butyl (4-chloro-3-hydroxyphenyl)carbamate|CS-0273187

Structure of 345893-27-8

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Description

Tert-butyl (4-chloro-3-hydroxyphenyl)carbamate features a hydroxylated aryl scaffold with a chlorine substituent at the para position, enabling selective functionalization in synthetic sequences. The tert-butyl carbamate group provides stable protection for primary amines under standard conditions, facilitating efficient deprotection via mild acidolysis. This combination delivers a robust, moisture-tolerant building block ideal for peptide and heterocyclic synthesis.

Application

Tert-butyl (4-chloro-3-hydroxyphenyl)carbamate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted phenolic scaffolds. The protected hydroxyl group offers enhanced stability and compatibility with diverse reaction conditions, while the chloro substituent facilitates subsequent cross-coupling or nucleophilic substitution. This compound functions effectively in multi-step syntheses requiring orthogonal protection strategies, particularly in the construction of complex heterocyclic and bioactive molecules.

General Information

CAS No. 345893-27-8
Cat. No. CS-0273187
Purity ≥98%
MDL No. None
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₄ClNO₃
Molecular Weight 243.69
Synonym(s) TERT-BUTYL 4-CHLORO-3-HYDROXYPHENYLCARBAMATE
SMILES CC(C)(OC(NC1=CC(O)=C(Cl)C=C1)=O)C

Computational Chemistry Data

TPSA 58.56
LogP 3.3926
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Phenol

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Tert-butyl (4-chloro-3-hydroxyphenyl)carbamate

CAS No. 345893-27-8

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