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Structure of 348-27-6
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2-Fluoro-4-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by electron-withdrawing fluorine and hydrogen-bonding hydroxyl functionalities. This combination enhances reactivity in coupling processes while maintaining stability under standard bench conditions. The molecule integrates readily into bioactive scaffolds requiring polar, ortho-substituted aromatic motifs.
2-Fluoro-4-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated phenolic motifs into bioactive scaffolds. Its ortho-fluoro and para-hydroxy substituents provide complementary reactivity for palladium-catalyzed coupling, electrophilic substitution, and directed metalation. The aldehyde functionality facilitates rapid access to imines, hydrazones, and heterocycles via standard condensation protocols. Bench-stable and amenable to purification by recrystallization or flash chromatography, it functions reliably in multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: