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Structure of 34813-49-5
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2-Methylpropane-2-sulfonamide is a sterically hindered sulfonamide featuring a tertiary carbon center, enhancing its stability and resistance to hydrolysis. This structural rigidity facilitates its use in bioactive molecule design, particularly as a metabolically stable amide surrogate in medicinal chemistry applications.
2-Methylpropane-2-sulfonamide serves as a stable, bench-ready sulfonamide building block for medicinal chemistry and process development. Its tertiary sulfonamide functionality exhibits excellent functional group tolerance and facilitates efficient coupling reactions in peptide and heterocyclic synthesis. The bulky tert-butyl-like structure enhances metabolic stability and modulates physicochemical properties in API candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: