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CS-W001157 4
Total: USD 88.00

2,4-Difluoropyridine

  • CAS No. 34941-90-7

  • Cat. No. CS-W011239
  • Purity≥98%
  • MDL No.MFCD04114162
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoropyridine|CS-W011239

Structure of 34941-90-7

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Description

2,4-Difluoropyridine is a fluorinated heterocycle featuring two strategically positioned fluorine atoms that enhance electrophilicity at the C2 and C4 positions. This electron-deficient pyridine derivative serves as a key scaffold in medicinal chemistry, enabling efficient coupling reactions and facilitating metabolic stability in bioactive molecules.

Application

2,4-Difluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at C3 via nucleophilic substitution due to the ortho/para directing effect of fluorine. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient access to diverse heterocyclic scaffolds. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive compounds, offering predictable regioselectivity and excellent functional group tolerance in standard synthetic workflows.

General Information

  • CAS No. 34941-90-7
  • Cat. No. CS-W011239
  • Purity ≥98%
  • MDL No. MFCD04114162
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃F₂N
  • Molecular Weight 115.08
  • Synonym(s) 2,4-DIFLUORO-PYRIDINE
  • SMILES FC1=NC=CC(=C1)F

Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.3598
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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