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CS-W001157 4
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4-Chloro-2-fluoropyridine

  • CAS No. 34941-92-9

  • Cat. No. CS-W019166
  • Purity≥98%
  • MDL No.MFCD04112503

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-fluoropyridine|CS-W019166

Structure of 34941-92-9

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General Information

  • CAS No. 34941-92-9
  • Cat. No. CS-W019166
  • Purity ≥98%
  • MDL No. MFCD04112503
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFN
  • Molecular Weight 131.54
  • Synonym(s) Pyridine,4-chloro-2-fluoro-; 4-Chloro-2-fluoropyridine
  • SMILES ClC1=CC(=NC=C1)F

Description

4-Chloro-2-fluoropyridine is a fluorinated heterocyclic building block featuring orthogonal reactivity at the 2- and 4-positions. This electron-deficient pyridine integrates readily into pharmaceutical intermediates, enabling selective functionalization under mild conditions. The molecule exhibits enhanced metabolic stability and favorable solubility profiles in polar aprotic solvents.

Application

4-Chloro-2-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The fluorine and chlorine substituents provide distinct electronic effects and facilitate selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8741
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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