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Structure of 351002-90-9
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2-(4-Ethynylphenyl)acetonitrile features a terminal alkyne tethered to a para-substituted phenyl ring, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC). The nitrile group provides enhanced solubility and stability under standard reaction conditions. This scaffold integrates readily into bioconjugation workflows and functional materials synthesis.
2-(4-Ethynylphenyl)acetonitrile serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated aryl-alkyne architectures. The molecule combines a terminal alkyne and nitrile functionality, offering orthogonal reactivity for Sonogashira couplings and subsequent transformations. Its bench-stable nature and straightforward purification make it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: