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Structure of 35203-49-7
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N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. The methylated amine nitrogen improves solubility and reduces basicity compared to the parent diamine. This compound serves as a key building block for functionalized aromatic scaffolds in medicinal chemistry and materials science.
N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of functionalized heterocycles and bioactive scaffolds. Its ortho-diamine motif facilitates cyclization reactions with carbonyl electrophiles, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The N-methyl substitution improves solubility and reduces basicity, offering favorable handling and purification characteristics. This compound functions effectively in standard coupling and condensation protocols for API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: