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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid

  • CAS No. 352523-15-0

  • Cat. No. CS-0188307
  • Molecule weight455.43
  • Purity≥98%
  • MDL No.MFCD01863051

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid|CS-0188307

Structure of 352523-15-0

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General Information

  • CAS No. 352523-15-0
  • Cat. No. CS-0188307
  • Purity ≥98%
  • MDL No. MFCD01863051
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₀F₃NO₄
  • Molecular Weight 455.43
  • Synonym(s) None
  • SMILES O=C(O)[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CC4=CC=CC=C4C(F)(F)F

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid is a chiral building block featuring a fluorenylmethoxycarbonyl (Fmoc) protected amino group and a sterically influenced trifluoromethyl-substituted aryl side chain. This configuration enables efficient incorporation into peptide synthesis workflows, offering enhanced solubility and stability under standard conditions.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid serves as a robust chiral building block for peptide synthesis, offering high stereoselectivity and bench stability. The Fmoc group enables orthogonal protection, while the trifluoromethylphenyl side chain provides enhanced metabolic stability and lipophilicity—valuable traits in medicinal chemistry. Its compatibility with standard coupling protocols and ease of purification make it a practical choice for synthesizing biologically active peptides and scaffold libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   5.2398
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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