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Structure of 352655-40-4
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(R)-3,5-iPr-4-NMe2-MeOBIPHEP features a sterically hindered biphenyl scaffold with electron-donating N-methylamino and methoxy substituents, delivering enhanced chiral recognition in asymmetric catalysis. This bench-stable ligand enables high enantioselectivity in palladium-catalyzed cross-coupling reactions under standard conditions.
(R)-3,5-iPr-4-NMe₂-MeOBIPHEP serves as a highly effective chiral ligand in transition metal-catalyzed asymmetric synthesis, particularly in palladium- and nickel-mediated cross-coupling reactions. Its sterically demanding isopropyl groups and electron-donating N-methylamino and methoxy substituents enhance enantioselectivity and catalyst stability. The ligand demonstrates excellent functional group tolerance and facilitates efficient coupling of challenging substrates, enabling reliable access to enantiomerically enriched biaryl scaffolds critical in pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: