Thiazolo[4,5-h]isoquinolin-2-amine

Name: Thiazolo[4,5-h]isoquinolin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 35317-80-7
Cat. No. CS-0006110
Purity≥98%
MDL No.MFCD22199995

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Thiazolo[4,5-h]isoquinolin-2-amine|CS-0006110

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General Information

CAS No. 35317-80-7
Cat. No. CS-0006110
Purity ≥98%
MDL No. MFCD22199995
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₇N₃S
Molecular Weight 201.25
Synonym(s) Thiazolo[4,5-h]isoquinolin-2-amine (9CI)
SMILES NC(S1)=NC2=C1C3=C(C=C2)C=CN=C3

Description

Thiazolo[4,5-h]isoquinolin-2-amine delivers a rigid, electron-deficient heteroaromatic scaffold with enhanced planarity and improved solubility compared to analogous systems. This structural motif integrates seamlessly into kinase inhibitors and photoluminescent materials, offering high thermal stability and predictable binding geometry in medicinal chemistry applications.

Application

Thiazolo[4,5-h]isoquinolin-2-amine serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling the construction of bioactive molecules through its electron-rich core and defined nitrogen positioning. The compound functions as a key building block for kinase inhibitors and other target-directed therapeutics, offering robust bench stability and compatibility with standard coupling reactions. Its fused ring system provides structural rigidity and enhanced metabolic resistance, facilitating efficient synthesis and purification in multi-step routes.

Synthesis

Route1
- In-stock
  
  23707-37-1
- 333-20-0
- ~%
- In-stock
  
  35317-80-7
References
- Taurins,A.; Hsia,R.K.-C. Canadian Journal of Chemistry, 1971 , vol. 49, p. 4054 - 4064

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 51.8
LogP 2.4267
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Isoquinoline compounds

Building Blocks Skeleton Aromatic heterocycle compounds Benzothiazole compounds

Key Words

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Thiazolo[4,5-h]isoquinolin-2-amine

CAS No. 35317-80-7

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