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CS-W001157 4
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3-Chloro-1-(4-methoxyphenyl)propan-1-one

  • CAS No. 35999-20-3

  • Cat. No. CS-W015648
  • Purity≥97%
  • MDL No.MFCD00236602

*For research and further manufacturing use only, not for direct human use.

3-Chloro-1-(4-methoxyphenyl)propan-1-one|CS-W015648

Structure of 35999-20-3

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General Information

  • CAS No. 35999-20-3
  • Cat. No. CS-W015648
  • Purity ≥97%
  • MDL No. MFCD00236602
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁ClO₂
  • Molecular Weight 198.65
  • Synonym(s) BETA-CHLORO-4-METHOXYPROPIOPHENONE
  • SMILES O=C(C1=CC=C(OC)C=C1)CCCl

Description

This electrophilic ketone features a para-methoxyphenyl group that enhances solubility and modulates reactivity. The chlorine substituent at the alpha position enables facile nucleophilic substitution, streamlining access to functionalized aromatic scaffolds in synthetic workflows.

Application

3-Chloro-1-(4-methoxyphenyl)propan-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted phenylalkyl scaffolds. Its electrophilic carbonyl and activated α-halo position facilitate nucleophilic addition, condensation reactions, and C–C bond formation under mild conditions. The molecule exhibits good bench stability and compatibility with common protecting groups, simplifying purification and integration into multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.

Synthesis

  • Route1
    • null|null
      100-66-3
    • null|null
      625-36-5
    • ~99%
    • In-stock
      3-Chloro-1-(4-methoxyphenyl)propan-1-one|CS-W015648
      35999-20-3

    References

    • Stephan, Holger; Geipel, Gerhard; Bernhard, Gert; Comba, Peter; Rajaraman, Gopalan; Hahn, Uwe; Voegtle, Fritz European Journal of Inorganic Chemistry, 2005 , # 22 p. 4501 - 4508
  • Route2
    • null|null
      107-94-8
    • ~%
    • In-stock
      3-Chloro-1-(4-methoxyphenyl)propan-1-one|CS-W015648
      35999-20-3

    References

    • Journal of the Chemical Society, , p. 299,301 Chemische Berichte, , vol. 69, p. 16,17 Journal of the American Chemical Society, , vol. 67, p. 1466 Canadian Journal of Research, , vol. 8, p. 440,444 Recueil des Travaux Chimiques des Pays-Bas, , vol. 67, p. 998,1002

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.5068
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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