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Structure of 361476-01-9
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5-Bromo-1-methyl-1H-pyrazole is a brominated pyrazole derivative featuring a methyl group at the 1-position and a bromine substituent at the 5-position. This electron-deficient heterocycle serves as a valuable building block in medicinal chemistry, enabling direct incorporation into bioactive molecules through cross-coupling reactions. The compound exhibits enhanced stability under standard bench conditions and compatibility with diverse reaction environments.
5-Bromo-1-methyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromine substituent facilitates Suzuki, Stille, and Negishi couplings, while the methylated pyrazole core offers enhanced metabolic stability and favorable pharmacophore geometry. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step syntheses of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: