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CS-W001157 4
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5-Chlorothiophene-3-carboxylic acid

  • CAS No. 36157-42-3

  • Cat. No. CS-W019291
  • Purity≥97%
  • MDL No.MFCD00082877

*For research and further manufacturing use only, not for direct human use.

5-Chlorothiophene-3-carboxylic acid|CS-W019291

Structure of 36157-42-3

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General Information

  • CAS No. 36157-42-3
  • Cat. No. CS-W019291
  • Purity ≥97%
  • MDL No. MFCD00082877
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClO₂S
  • Molecular Weight 162.59
  • Synonym(s) Rivaroxaban Impurity 78
  • SMILES ClC1=CC(=CS1)C(=O)O

Description

5-Chlorothiophene-3-carboxylic acid features a chlorinated thiophene core paired with a carboxylic acid group, enabling direct integration into heterocyclic scaffolds. This electron-deficient moiety facilitates coupling reactions and serves as a key building block in pharmaceutical intermediates and functional materials.

Application

5-Chlorothiophene-3-carboxylic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, enabling efficient incorporation of chlorine and carboxylic acid functionalities into complex scaffolds. Its stability, compatibility with standard coupling reactions, and utility in late-stage functionalization make it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 76, p. 2445
  • Route2
    • 5-Chlorothiophene-3-carbaldehyde|CS-W006694
      36155-85-8
    • ~%
    • In-stock
      5-Chlorothiophene-3-carboxylic acid|CS-W019291
      36157-42-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 21 p. 5567 - 5571
  • Route3

    References

    • Monatshefte fuer Chemie, , vol. 120, p. 53 - 63

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.0997
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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