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Structure of 364-13-6
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2-(Trifluoromethyl)benzene-1,4-diamine features a para-substituted aromatic core bearing both an electron-withdrawing trifluoromethyl group and two primary amine functionalities. This combination imparts enhanced solubility and stability under standard conditions, enabling direct use in coupling reactions and as a building block for functionalized polymers and bioactive molecules.
2-(Trifluoromethyl)benzene-1,4-diamine serves as a valuable building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds and functionalized aromatic systems. Its dual primary amine functionality exhibits excellent compatibility with standard coupling reactions, including amidations, reductive aminations, and electrophilic substitutions. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it particularly useful in drug discovery campaigns targeting CNS and oncology indications. Bench-stable and readily purified by recrystallization, it facilitates scalable synthesis and integration into multi-step sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: