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CS-W001157 4
Total: USD 88.00

(2-((Methylamino)methyl)phenyl)boronic acid

  • CAS No. 365245-83-6

  • Cat. No. CS-0151002
  • Purity≥98%
  • MDL No.MFCD18453444

*For research and further manufacturing use only, not for direct human use.

(2-((Methylamino)methyl)phenyl)boronic acid|CS-0151002

Structure of 365245-83-6

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General Information

  • CAS No. 365245-83-6
  • Cat. No. CS-0151002
  • Purity ≥98%
  • MDL No. MFCD18453444
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂BNO₂
  • Molecular Weight 165.00
  • Synonym(s) 2-((MethylaMino)Methyl)phenylboronic acid
  • SMILES CNCC1=CC=CC=C1B(O)O

Description

This boronate moiety integrates a methylaminomethyl substituent at the ortho position of a phenyl ring, delivering enhanced solubility and stability under standard conditions. The pendant amine facilitates conjugation and functionalization in synthetic workflows, while the boronic acid group enables efficient Suzuki-Miyaura coupling reactions.

Application

(2-((Methylamino)methyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability, ease of handling, and compatibility with diverse functional groups make it ideal for constructing biaryl scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • In-stock
      (2-Formylphenyl)boronic acid|CS-W007320
      40138-16-7
    • null|null
      74-89-5
    • ~91%
    • In-stock
      (2-((Methylamino)methyl)phenyl)boronic acid|CS-0151002
      365245-83-6

    References

    • Swamy; Jang, Yun Jung; Park, Min Sun; Koh, Hwa Soo; Lee, Sang Kil; Yoon, Yeo Joon; Yoon, Juyoung Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3453 - 3456
  • Route2

    References

    • Boudreault, Pierre-Luc; Cardinal, Sebastien; Voyer, Normand Synlett, 2010 , # 16 p. 2449 - 2452

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.49
  • LogP   -0.9142
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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