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CS-W001157 4
Total: USD 88.00

N-(4-Ethylphenyl)acetamide

  • CAS No. 3663-34-1

  • Cat. No. CS-0226195
  • Molecule weight163.22
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-(4-Ethylphenyl)acetamide|CS-0226195

Structure of 3663-34-1

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General Information

  • CAS No. 3663-34-1
  • Cat. No. CS-0226195
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO
  • Molecular Weight 163.22
  • Synonym(s) p-Ethylacetanilide
  • SMILES CC(NC1=CC=C(CC)C=C1)=O

Description

N-(4-Ethylphenyl)acetamide is a bench-stable aromatic amide featuring a para-ethyl-substituted phenyl ring linked via an acetamide tether. This configuration delivers enhanced solubility in organic solvents and facilitates integration into pharmaceutical intermediates and functional materials, where its electron-rich aryl group supports efficient coupling reactions under standard conditions.

Application

N-(4-Ethylphenyl)acetamide serves as a versatile intermediate in medicinal chemistry, enabling efficient construction of aromatic amide scaffolds. Its ethyl-substituted phenyl ring enhances lipophilicity and metabolic stability, while the acetamide group provides a robust handle for further functionalization via hydrolysis, reduction, or coupling reactions. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows for API development and heterocyclic core assembly.

Synthesis

  • Route1

    References

    • Takasago International Corporation Patent: US6228547 B1, 2001 ;
  • Route2
    • null|null
      108-24-7
    • In-stock
      4-Ethylaniline|CS-W020122
      589-16-2
    • ~10%
    • In-stock
      N-(4-Ethylphenyl)acetamide|CS-0226195
      3663-34-1

    References

    • Mazaheritehrani; Asghari; Orimi, R. Lotfi; Pahlavan Asian Journal of Chemistry, 2010 , vol. 22, # 4 p. 2554 - 2564
  • Route3
    • null|null
      100-12-9
    • null|null
      10387-40-3
    • ~86%
    • In-stock
      N-(4-Ethylphenyl)acetamide|CS-0226195
      3663-34-1

    References

    • THE TEXAS A and M UNIVERSITY SYSTEM Patent: WO2006/23763 A1, 2006 ; Location in patent: Page/Page column 12; 13 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.2074
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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