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CS-W001157 4
Total: USD 88.00

4-Fluorobenzenesulphonic Acid

  • CAS No. 368-88-7

  • Cat. No. CS-0187013
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzenesulphonic Acid|CS-0187013

Structure of 368-88-7

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General Information

  • CAS No. 368-88-7
  • Cat. No. CS-0187013
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FO₃S
  • Molecular Weight 176.17
  • Synonym(s) p-Fluorophenylsulfonic acid
  • SMILES C1=C(C=CC(=C1)S(=O)(=O)O)F

Description

4-Fluorobenzenesulphonic acid features a fluorinated aromatic ring paired with a strongly acidic sulfonic group, enabling robust electrophilic substitution and enhanced solubility in polar media. This combination facilitates efficient coupling reactions and serves as a key intermediate in pharmaceutical synthesis and specialty polymer development under standard conditions.

Application

4-Fluorobenzenesulphonic acid serves as a versatile, bench-stable building block for sulfonation and electrophilic aromatic substitution reactions. Its fluorinated aryl moiety enhances metabolic stability in pharmaceutical intermediates, while the sulfonic acid group enables efficient salt formation and purification. Functions effectively in coupling sequences and heterocycle synthesis, offering high functional group tolerance and compatibility with standard reaction conditions.

Synthesis

  • Route1

    References

    • Bahrami, Kiumars; Khodaei, Mohammad M.; Abbasi, Jamshid Synthesis, 2012 , vol. 2012, # 2 p. 316 - 322
  • Route2
    • 1,2-Bis(4-fluorophenyl)disulfane|CS-0128788
      405-31-2
    • ~91%
    • In-stock
      4-Fluorobenzenesulphonic Acid|CS-0187013
      368-88-7

    References

    • Bahrami, Kiumars; Khodaei, Mohammad M.; Abbasi, Jamshid Synthesis, 2012 , vol. 2012, # 2 p. 316 - 322
  • Route3

    References

    • Herd, Oliver; Hessler, Antonella; Langhans, Klaus P.; Stelzer, Othmar; Sheldrick, William S.; Weferling, Norbert Journal of Organometallic Chemistry, 1994 , vol. 475, # 1-2 p. 99 - 112

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.0724
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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