2-Amino-5-chloro-4-picoline

Name: 2-Amino-5-chloro-4-picoline
Brand: ChemScene
Availability: InStock
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CAS No. 36936-27-3
Cat. No. CS-W003288
Purity≥98%
MDL No.MFCD06410759

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 36936-27-3

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Description

2-Amino-5-chloro-4-picoline features a strategically positioned chloro group flanking an electron-rich amino substituent on a picoline scaffold, enabling selective functionalization in heterocyclic synthesis. This bench-stable derivative facilitates direct coupling reactions and serves as a key intermediate in pharmaceutical and agrochemical development.

Application

2-Amino-5-chloro-4-picoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its ortho-amino and chloro functionalities provide complementary reactivity for sequential functionalization, while the picoline core ensures good bench stability and solubility in common organic solvents.

General Information

CAS No. 36936-27-3
Cat. No. CS-W003288
Purity ≥98%
MDL No. MFCD06410759
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight 142.59
Synonym(s) 5-Chloro-4-methylpyridin-2-amine
SMILES Nc1ncc(c(c1)C)Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.62562
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Amino-5-chloro-4-picoline

CAS No. 36936-27-3

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