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Structure of 36983-36-5
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Ethyl 2,4-dioxo-4-(thiophen-2-yl)butanoate serves as a key synthon in heterocyclic synthesis, featuring a thiophene-appended β-keto ester motif. The molecule integrates readily into Michael additions and cycloaddition cascades, leveraging its electron-deficient enone system and dual carbonyl functionalities for efficient ring formation under mild conditions.
Ethyl 2,4-dioxo-4-(thiophen-2-yl)butanoate serves as a versatile synthon in heterocyclic synthesis, enabling efficient access to functionalized pyrroles and thiophenes via condensation and cyclization reactions. Its α,β-unsaturated β-ketoester motif facilitates nucleophilic addition and Michael-type processes, while the thiophene moiety imparts stability and orthogonality for downstream modifications. The compound exhibits good bench stability and is amenable to standard purification protocols, making it a reliable building block for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: