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Structure of 373604-28-5
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tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate features a fluorinated piperidine core with a pendant hydroxyl group, enabling direct functionalization in medicinal chemistry. The tert-butyl carbamate protects the amine under standard conditions, while the 3-fluoro substituent enhances metabolic stability and modulates electronic properties. This scaffold integrates readily into bioactive molecules requiring polar, hydrogen-bonding motifs.
tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate serves as a versatile scaffold for the synthesis of fluorinated piperidine derivatives. The pendant hydroxyl group enables straightforward functionalization via esterification, etherification, or oxidation to ketone, while the tert-butoxycarbonyl (Boc) group provides robust protection for the amine during multi-step sequences. Its bench-stable nature and compatibility with standard coupling and reduction conditions make it a practical building block in medicinal chemistry campaigns targeting bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: