tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

Name: tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1174020-43-9
Cat. No. CS-0048568
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate|CS-0048568

Structure of 1174020-43-9

Size

Price

Quantity

* Please select Quantity before adding items.

Description

tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a fluorine atom at the 3-position and a hydroxyl group at the 4-position. This configuration enhances metabolic stability while maintaining favorable conformational bias for targeted applications in medicinal chemistry. The tert-butyl carbamate handle enables straightforward deprotection under mild acidic conditions.

Application

tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate serves as a stereochemically defined building block for fluorinated piperidine scaffolds prevalent in medicinal chemistry. The protected hydroxyl group enables selective derivatization, while the C3-fluoro substituent imparts metabolic stability and modulates bioavailability. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate efficient access to complex heterocyclic architectures in API development.

General Information

CAS No. 1174020-43-9
Cat. No. CS-0048568
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈FNO₃
Molecular Weight 219.25
Synonym(s) trans-tert-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
SMILES CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H](F)C1

Computational Chemistry Data

TPSA 49.77
LogP 1.3262
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

1174020-43-9 sigma1174020-43-9 manufacturer1174020-43-9 price1174020-43-9 structure1174020-43-9 SDSbuy 1174020-43-91174020-43-9 supplier1174020-43-9 uses1174020-43-9 molecular weightprice of 1174020-43-91174020-43-9 chemical name formula of 1174020-43-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

CAS No. 1174020-43-9

Recommended Products