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Structure of 37828-19-6
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1-Phenylcyclobutanecarboxylic acid features a rigid cyclobutane core fused to a phenyl ring, delivering enhanced metabolic stability and defined spatial orientation. This structural motif enables precise molecular positioning in drug discovery campaigns, particularly in targeting conformationally restricted bioactive scaffolds. The carboxylic acid group provides a versatile handle for derivatization, facilitating conjugation or salt formation under standard conditions.
1-Phenylcyclobutanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds and cyclobutane-based drug candidates. Its rigid, three-dimensional structure imparts conformational constraint, enhancing target selectivity and metabolic stability. The carboxylic acid functionality facilitates direct derivatization—such as amide formation, esterification, or activation for coupling reactions—while the phenyl ring supports further functionalization via electrophilic substitution. Bench-stable and readily purified by recrystallization, it functions effectively in both small-molecule synthesis and high-throughput screening campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: