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CS-W001157 4
Total: USD 88.00

3-Phenylcyclobutanecarboxylic acid

  • CAS No. 66016-28-2

  • Cat. No. CS-W000558
  • Purity≥98%
  • MDL No.MFCD01734191
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Phenylcyclobutanecarboxylic acid|CS-W000558

Structure of 66016-28-2

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Description

3-Phenylcyclobutanecarboxylic acid features a rigid cyclobutane core fused to a phenyl ring, delivering enhanced structural stability and defined spatial orientation. This configuration supports precise molecular recognition in synthetic applications. The carboxylic acid group enables direct derivatization or salt formation for improved solubility and handling. Its bench-stable nature facilitates use in multi-step synthesis without degradation.

Application

3-Phenylcyclobutanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds through standard functional group transformations. Its rigid cyclobutane core imparts conformational constraint, enhancing target binding affinity in drug discovery. The carboxylic acid functionality facilitates direct coupling reactions and derivatization, while the phenyl substituent offers π-stacking potential and synthetic handle for further modification. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses.

General Information

  • CAS No. 66016-28-2
  • Cat. No. CS-W000558
  • Purity ≥98%
  • MDL No. MFCD01734191
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(O)C1CC(C2=CC=CC=C2)C1

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.2648
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P337+P313-P362+P364-P501

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