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CS-W001157 4
Total: USD 88.00

3-Chloro-4-methoxybenzoic acid

  • CAS No. 37908-96-6

  • Cat. No. CS-W016880
  • Purity≥98%
  • MDL No.MFCD00016512

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-methoxybenzoic acid|CS-W016880

Structure of 37908-96-6

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General Information

  • CAS No. 37908-96-6
  • Cat. No. CS-W016880
  • Purity ≥98%
  • MDL No. MFCD00016512
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClO₃
  • Molecular Weight 186.59
  • Synonym(s) 3-Chloro-p-anisic Acid
  • SMILES COC1=C(Cl)C=C(C=C1)C(O)=O

Description

3-Chloro-4-methoxybenzoic acid features a chlorine atom at the meta position and a methoxy group at the para position relative to the carboxylic acid, delivering enhanced electron-withdrawing character and improved solubility in organic solvents. This combination enables efficient coupling reactions in pharmaceutical synthesis and facilitates derivatization under mild conditions.

Synthesis

  • Route1
    • p-Anisic acid, ≥99%|CS-1268349
      100-09-4
    • ~66%
    • In-stock
      3-Chloro-4-methoxybenzoic acid|CS-W016880
      37908-96-6

    References

    • AKAAL PHARMA PTY LTD; GILL, Gurmit, S.; GROBELNY, Damian, W. Patent: WO2010/42998 A1, 2010 ; Location in patent: Page/Page column 51; 52 ; WO 2010/042998 A1
  • Route2

    References

    • Riggs; Nichols; Foreman; Truex Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
  • Route3

    References

    • Riggs; Nichols; Foreman; Truex Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.0468
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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