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Structure of 453-71-4
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4-Fluoro-3-nitrobenzoic acid was used:as starting reagent in the preparation of novel benzimidazoles having antimycobacterial activityin preparation of series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structurein preparation of bis(heterocyclic) skeletal precursors for the Pictet-Spengler reactionin solid-phase synthesis of trisubstituted [1,3,5]triazino[1,2-a]benzimidazole-2,4(3H,10H)-diones
4-Fluoro-3-nitrobenzoic acid serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling direct functionalization at the aromatic ring through nucleophilic substitution or transition-metal-catalyzed coupling reactions. The ortho-fluoro and meta-nitro groups provide complementary reactivity for selective transformations, while the carboxylic acid facilitates amide formation or salt generation. Its bench-stable crystalline form enables straightforward handling and purification, making it ideal for constructing bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: