Methyl 2-amino-4,6-difluorobenzoate

Name: Methyl 2-amino-4,6-difluorobenzoate
Brand: ChemScene
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CAS No. 379228-57-6
Cat. No. CS-0042662
Purity≥98%
MDL No.MFCD12159819

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Methyl 2-amino-4,6-difluorobenzoate|CS-0042662

Structure of 379228-57-6

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Description

Methyl 2-amino-4,6-difluorobenzoate features a strategically positioned amino group flanked by two fluorine atoms, enabling enhanced electronic modulation in synthetic intermediates. This bench-stable compound integrates readily into pharmaceutical and agrochemical scaffolds, offering high reactivity under standard coupling conditions.

Application

Methyl 2-amino-4,6-difluorobenzoate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocycles and bioactive scaffolds. The ortho-amino group facilitates direct functionalization or cyclization, while the difluoro substitution pattern enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by column chromatography, it participates reliably in Pd-catalyzed cross-couplings and amide bond formations, making it well-suited for iterative synthesis workflows in API development.

General Information

CAS No. 379228-57-6
Cat. No. CS-0042662
Purity ≥98%
MDL No. MFCD12159819
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇F₂NO₂
Molecular Weight 187.14
Synonym(s) Methyl 2,4-difluoro-6-aminobenzoate
SMILES O=C(OC)C1=C(F)C=C(F)C=C1N

Computational Chemistry Data

TPSA 52.32
LogP 1.3336
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Methyl 2-amino-4,6-difluorobenzoate

CAS No. 379228-57-6

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