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CS-W001157 4
Total: USD 88.00

2-Bromo-5-fluoro-3-methylpyridine

  • CAS No. 38186-85-5

  • Cat. No. CS-W015920
  • Molecule weight190.01
  • Purity≥97%
  • MDL No.MFCD09835355

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-fluoro-3-methylpyridine|CS-W015920

Structure of 38186-85-5

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General Information

  • CAS No. 38186-85-5
  • Cat. No. CS-W015920
  • Purity ≥97%
  • MDL No. MFCD09835355
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) 2-bromo-5-fluoro-3-methyl-pyridine; 2-Bromo-5-fluoro-3-methylpyridine
  • SMILES BrC1=NC=C(C=C1C)F

Description

2-Bromo-5-fluoro-3-methylpyridine features a trifunctional pyridine core enabling seamless integration into diverse synthetic pathways. The ortho-bromo and para-fluoro substituents facilitate cross-coupling reactions, while the methyl group enhances regioselectivity. This bench-stable, moisture-tolerant heterocycle serves as a key building block for pharmaceutical intermediates and functional materials.

Application

2-Bromo-5-fluoro-3-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine and methyl substituents offer orthogonal functionalization potential. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for modular heterocycle synthesis and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.29162
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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