2-Chloro-5-fluoronicotinic acid

Name: 2-Chloro-5-fluoronicotinic acid
Brand: ChemScene
Availability: InStock
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CAS No. 38186-88-8
Cat. No. CS-W007407
Purity≥98%
MDL No.MFCD03092932

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Chloro-5-fluoronicotinic acid|CS-W007407

Structure of 38186-88-8

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Description

2-Chloro-5-fluoronicotinic acid features a strategically positioned chloro and fluoro substituent on the nicotinic acid scaffold, enhancing electron deficiency and metabolic stability. This configuration supports direct incorporation into bioactive heterocycles, enabling efficient access to pharmaceutical intermediates under standard conditions.

Application

2-Chloro-5-fluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid group allows for direct derivatization or incorporation into peptide-like scaffolds. The molecule exhibits good bench stability and functional group tolerance, supporting efficient purification and integration into multi-step synthetic sequences.

General Information

CAS No. 38186-88-8
Cat. No. CS-W007407
Purity ≥98%
MDL No. MFCD03092932
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO₂
Molecular Weight 175.55
Synonym(s) 2-Butanone, 1,1,1-trifluoro-
SMILES ClC1=C(C(=O)O)C=C(C=N1)F

Computational Chemistry Data

TPSA 50.19
LogP 1.5723
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-fluoronicotinic acid

CAS No. 38186-88-8

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