N-t-Butylpiperazine

Name: N-t-Butylpiperazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 38216-72-7
Cat. No. CS-W002238
Purity≥97%
MDL No.MFCD00049359

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

N-t-Butylpiperazine is a sterically hindered piperazine derivative featuring a bulky tert-butyl group that enhances its stability and solubility in organic media. This substitution reduces basicity while preserving nucleophilicity, enabling efficient incorporation into complex molecular architectures. The compound serves as a robust scaffold for medicinal chemistry campaigns, particularly in optimizing pharmacokinetic profiles through improved metabolic resistance.

Application

N-t-Butylpiperazine serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient access to complex heterocyclic scaffolds. Its tertiary amine functionality exhibits excellent stability and compatibility with standard synthetic protocols, facilitating straightforward functionalization and purification. The t-butyl group enhances solubility and steric shielding, improving metabolic stability in downstream applications. This compound functions effectively in amide coupling, reductive amination, and transition-metal-catalyzed cross-coupling reactions, making it a practical choice for lead optimization and API intermediate synthesis.

General Information

CAS No. 38216-72-7
Cat. No. CS-W002238
Purity ≥97%
MDL No. MFCD00049359
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₈N₂
Molecular Weight 142.24
Synonym(s) 1-Tert-butylpiperazine
SMILES CC(N1CCNCC1)(C)C

Computational Chemistry Data

TPSA 15.27
LogP 0.6901
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS09
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314-H400
Precautionary Statements : P264-P271-P280-P301+P330+P331-P304+P340-P363-P501

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N-t-Butylpiperazine

CAS No. 38216-72-7

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