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CS-W001157 4
Total: USD 88.00

3-(Aminomethyl)-6-(trifluoromethyl)pyridine

  • CAS No. 387350-39-2

  • Cat. No. CS-W006446
  • Molecule weight176.14
  • Purity≥97%
  • MDL No.MFCD01862649

*For research and further manufacturing use only, not for direct human use.

3-(Aminomethyl)-6-(trifluoromethyl)pyridine|CS-W006446

Structure of 387350-39-2

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General Information

  • CAS No. 387350-39-2
  • Cat. No. CS-W006446
  • Purity ≥97%
  • MDL No. MFCD01862649
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₃N₂
  • Molecular Weight 176.14
  • Synonym(s) 1-[6-(trifluoromethyl)pyridin-3-yl]methanamine
  • SMILES NCC1=CC=C(N=C1)C(F)(F)F

Description

This pyridine derivative features a strategically positioned aminomethyl group and a trifluoromethyl moiety, enabling robust functionalization in synthetic pathways. The electron-withdrawing trifluoromethyl substituent enhances reactivity at the pyridine ring while maintaining stability under standard conditions. Ideal for coupling reactions and as a building block in medicinal chemistry and agrochemical development.

Application

3-(Aminomethyl)-6-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling direct access to bioactive heterocyclic scaffolds. The primary amine functionality facilitates conjugation and derivatization, while the trifluoromethyl group enhances metabolic stability and lipophilicity. Its pyridine core supports standard coupling reactions and functional group interconversions, making it suitable for modular synthesis of kinase inhibitors and other targeted therapeutics. The compound exhibits good bench stability and is readily purified by standard chromatographic methods.

Synthesis

  • Route1
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      1108556-21-3
    • ~%
    • In-stock
      3-(Aminomethyl)-6-(trifluoromethyl)pyridine|CS-W006446
      387350-39-2

    References

    • COMENTIS, INC.; PURDUE RESEARCH FOUNDATION Patent: WO2009/42694 A1, 2009 ; Location in patent: Page/Page column 96 ; WO 2009/042694 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P280-P301+P330+P331-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5591
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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