Methyl succinate

Name: Methyl succinate
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CAS No. 3878-55-5
Cat. No. CS-W011096
Purity≥97%
MDL No.MFCD00002788

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

DMT-2O-Methyl-rC(ac) Phosphoramidite is one of the 2O-Methyl RNA monomers that feature methoxy groups at the 2-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:High yield of crude oligonucleotidesCompatible with DNA synthesisCan be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides Recommended deprotection conditions are 8 hours at 55 C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 CPurification and other downstream processing of fully modified 2OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation Synthesis of 2O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)2O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry2O-Methyl RNA nucleoside including DMT-2O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2O-Methyl RNA had found widespread use in the fields of: Diagnostic probes Aptamer and ribozyme development Mixed 2O-Methyl-RNA/DNA antisense molecules

General Information

CAS No. 3878-55-5
Cat. No. CS-W011096
Purity ≥97%
MDL No. MFCD00002788
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₈O₄
Molecular Weight 132.11
Synonym(s) None
SMILES O=C(CCC(OC)=O)O

Computational Chemistry Data

TPSA 63.6
LogP 0.0242
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Natural Products

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Ester

Building Blocks Skeleton Fatty chain compounds

General Reagents Organic General Reagents

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Methyl succinate

CAS No. 3878-55-5

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