4-Chloro-6-fluoroquinoline

Name: 4-Chloro-6-fluoroquinoline
Brand: ChemScene
Availability: InStock
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CAS No. 391-77-5
Cat. No. CS-W005166
Purity≥98%
MDL No.MFCD00278783

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

4-Chloro-6-fluoroquinoline is a fluorinated quinoline derivative featuring complementary electron-withdrawing substituents at the 4- and 6-positions. This combination enhances its utility in medicinal chemistry, where it serves as a key scaffold for kinase inhibitors and fluorescent probes. The molecule exhibits favorable solubility and stability under standard conditions, enabling straightforward incorporation into diverse synthetic pathways.

Application

4-Chloro-6-fluoroquinoline serves as a versatile building block in medicinal chemistry and materials science, enabling direct functionalization at the C4 and C6 positions via palladium-catalyzed cross-coupling reactions. Its electron-deficient quinoline core enhances reactivity in nucleophilic substitution processes, while the halogen atoms provide orthogonal handles for sequential derivatization. Bench-stable and compatible with standard purification techniques, it facilitates efficient construction of complex heterocyclic scaffolds used in pharmaceutical development and advanced organic semiconductors.

General Information

CAS No. 391-77-5
Cat. No. CS-W005166
Purity ≥98%
MDL No. MFCD00278783
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅ClFN
Molecular Weight 181.59
Synonym(s) Quinoline, 4-chloro-6-fluoro-
SMILES C1=C(F)C=CC2=C1C(=CC=N2)Cl

Computational Chemistry Data

TPSA 12.89
LogP 3.0273
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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4-Chloro-6-fluoroquinoline

CAS No. 391-77-5

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