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CS-W001157 4
Total: USD 88.00

5-Ethylthiazol-2-amine

  • CAS No. 39136-60-2

  • Cat. No. CS-W022373
  • Purity≥97%
  • MDL No.MFCD00613421

*For research and further manufacturing use only, not for direct human use.

5-Ethylthiazol-2-amine|CS-W022373

Structure of 39136-60-2

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General Information

  • CAS No. 39136-60-2
  • Cat. No. CS-W022373
  • Purity ≥97%
  • MDL No. MFCD00613421
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈N₂S
  • Molecular Weight 128.20
  • Synonym(s) 5-ethyl-1,3-thiazol-2-amine
  • SMILES NC1=NC=C(CC)S1

Description

5-Ethylthiazol-2-amine features a thiazole core functionalized with an ethyl group at the 5-position and a primary amine at the 2-position. This combination imparts enhanced solubility and reactivity, enabling direct incorporation into pharmaceutical intermediates and bioactive heterocycles under standard conditions. The molecule exhibits bench-stable handling characteristics and serves as a key scaffold for targeted molecular design in medicinal chemistry.

Application

5-Ethylthiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds through standard coupling and functionalization reactions. Its ethyl substituent enhances lipophilicity and metabolic stability, while the primary amine group facilitates straightforward derivatization via amidation, alkylation, or electrophilic substitution. The compound exhibits good bench stability and is compatible with common reaction conditions, making it well-suited for modular synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      123-72-8
    • null|null
      17356-08-0
    • ~61%
    • In-stock
      5-Ethylthiazol-2-amine|CS-W022373
      39136-60-2

    References

    • Fan, Zhijin; Shi, Zugui; Zhang, Haike; Liu, Xiufeng; Bao, Lili; Ma, Lin; Zuo, Xiang; Zheng, Qinxiang; Mi, Na Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 10 p. 4279 - 4286
  • Route2
    • 5-Propylthiazol-2-amine|CS-0664418
      39136-61-3
    • null|null
      111-71-7
    • null|null
      123-72-8
    • ~%
    • In-stock
      5-Ethylthiazol-2-amine|CS-W022373
      39136-60-2

    References

    • Pfizer Inc. Patent: US4414388 A1, 1983 ;
  • Route3
    • null|null
      24764-97-4
    • null|null
      17356-08-0
    • ~%
    • In-stock
      5-Ethylthiazol-2-amine|CS-W022373
      39136-60-2

    References

    • Helal, Christopher J.; Sanner, Mark A.; Cooper, Christopher B.; Gant, Thomas; Adam, Mavis; Lucas, John C.; Kang, Zhijun; Kupchinsky, Stanley; Ahlijanian, Michael K.; Tate, Bonnie; Menniti, Frank S.; Kelly, Kristin; Peterson, Marcia Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5521 - 5525

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.2877
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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