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Structure of 392-25-6
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3,5-Difluoro-4-methoxynitrobenzene features a highly electron-deficient aromatic core stabilized by dual fluorine substituents and a methoxy nitro group. This configuration enables direct coupling in cross-coupling reactions under standard conditions, delivering functionalized intermediates with enhanced metabolic stability.
3,5-Difluoro-4-methoxynitrobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via nucleophilic aromatic substitution. The ortho-fluorine atoms facilitate selective displacement under mild conditions, while the methoxy and nitro groups provide orthogonal reactivity and enhanced solubility. Bench-stable and compatible with standard coupling protocols, it functions as a key scaffold for constructing complex heterocycles and bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: