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Structure of 394-32-1
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1-(5-Fluoro-2-hydroxyphenyl)ethanone features a fluorinated aromatic ring bearing a hydroxyl group at the ortho position and a ketone functionality, enabling direct integration into bioactive scaffolds. The electron-withdrawing fluorine enhances metabolic stability, while the phenolic OH facilitates hydrogen bonding in target interactions. This compound serves as a key intermediate in pharmaceutical synthesis.
1-(5-Fluoro-2-hydroxyphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted phenolic ketones. Its ortho-hydroxy and fluoro substituents provide enhanced reactivity for electrophilic aromatic substitution and facilitate downstream functionalization via directed metalation or coupling reactions. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: