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Structure of 395101-84-5
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3-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1-H-indazole-5-carboxamide is a bench-stable, moisture-tolerant heterocyclic building block featuring a brominated indazole core and a tetrahydropyran-protected amine. This combination enables direct incorporation into Suzuki-Miyaura couplings and late-stage diversification in medicinal chemistry campaigns.
3-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1-H-indazole-5-carboxamide serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling. The bromo group facilitates efficient C–C and C–heteroatom bond formation, while the tetrahydro-2H-pyran-2-yl protecting group ensures stability and orthogonal deprotection under mild acidic conditions. Its indazole core provides a rigid, planar scaffold with favorable pharmacophoric properties, making it well-suited for targeted synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: