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Structure of 39576-83-5
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2,4-Dichloro-8-methylquinazoline is a bench-stable, electron-deficient heterocycle featuring two chlorine substituents at positions 2 and 4 and a methyl group at position 8. This structural motif enables efficient coupling in transition metal-catalyzed cross-coupling reactions, serving as a key building block for functionalized quinazoline derivatives in medicinal chemistry and materials science.
2,4-Dichloro-8-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and other bioactive heterocycles. The dichloro substitution pattern facilitates regioselective nucleophilic aromatic substitution, while the methyl group at C8 enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with palladium-catalyzed coupling reactions make it ideal for modular synthesis of complex pharmaceutical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: